Journal article
Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling
K Nones, N Waddell, S Song, AM Patch, D Miller, A Johns, J Wu, KS Kassahn, D Wood, P Bailey, L Fink, S Manning, AN Christ, C Nourse, S Kazakoff, D Taylor, C Leonard, DK Chang, MD Jones, M Thomas Show all
International Journal of Cancer | Published : 2014
DOI: 10.1002/ijc.28765
Abstract
The importance of epigenetic modifications such as DNA methylation in tumorigenesis is increasingly being appreciated. To define the genome-wide pattern of DNA methylation in pancreatic ductal adenocarcinomas (PDAC), we captured the methylation profiles of 167 untreated resected PDACs and compared them to a panel of 29 adjacent nontransformed pancreata using high-density arrays. A total of 11,634 CpG sites associated with 3,522 genes were significantly differentially methylated (DM) in PDAC and were capable of segregating PDAC from non-malignant pancreas, regardless of tumor cellularity. As expected, PDAC hypermethylation was most prevalent in the 5 region of genes (including the proximal pr..
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Grants
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by Cancer Council NSW
Awarded by Cancer Institute NSW
Awarded by Italian Cancer Genome Project
Awarded by Italian Association for Cancer Research
Funding Acknowledgements
Grant sponsor: National Health and Medical Research Council of Australia (NHMRC); Grant number: 631701, 535903, 427601 and APP1047334; Grant sponsor: Australian Government: Department of Innovation, Industry, Science and Research (DIISR); Grant sponsor: Australian Cancer Research Foundation (ACRF); Grant sponsor: Queensland Government (NI-RAP); Grant sponsor: University of Queensland; Grant sponsor: Cancer Council NSW; Grant number: SRP06-01; Grant sponsor: Cancer Institute NSW; Grant number: 10/ECF/2-26, 06/ECF/1-24, 09/CDF/2-40, 07/CDF/1-03, 10/CRF/1-01, 08/RSA/1-15, 07/CDF/1-28, 10/CDF/2-26, 10/FRL/2-03, 06/RSA/1-05, 09/RIG/1-02, 10/TPG/1-04, 11/REG/1-10 and 11/CDF/3-26; Grant sponsor: Garvan Institute of Medical Research; Grant sponsor: AvnerNahmani Pancreatic Cancer Research Foundation; Grant sponsor: R.T. Hall Trust; Grant sponsor: Petre Foundation; Grant sponsor: Philip Hemstritch Foundation; Grant sponsor: Gastroenterological Society of Australia (GESA); Grant sponsor: American Association for Cancer Research (AACR) Landon Foundation INNOVATOR Award; Grant sponsor: Royal Australasian College of Surgeons (RACS); Grant sponsor: Royal Australasian College of Physicians (RACP); Grant sponsor: Royal College of Pathologists of Australasia (RCPA); Grant sponsor: NHMRC Principal Research Fellowship; Grant sponsor: Italian Cancer Genome Project; Grant number: FIRB RBAP10AHJB; Grant sponsor: Italian Association for Cancer Research; Grant number: 12182